Improvement of vascular function by acute and chronic treatment with the PDE-5 inhibitor sildenafil in experimental diabetes mellitus.

@article{Schaefer2008ImprovementOV,
  title={Improvement of vascular function by acute and chronic treatment with the PDE-5 inhibitor sildenafil in experimental diabetes mellitus.},
  author={Andreas Schaefer and Daniela Fraccarollo and Stephanie Pfoertsch and Ulrike Flierl and Christian Vogt and Julia Pfrang and Anna L Kobsar and Thomas Renn{\'e} and Martin Eigenthaler and Georg Ertl and Johann Bauersachs},
  journal={British journal of pharmacology},
  year={2008},
  volume={153 5},
  pages={
          886-93
        }
}
BACKGROUND AND PURPOSE Diabetes-associated vascular dysfunction contributes to increased cardiovascular risk. We investigated whether the phosphodiesterase-5 inhibitor sildenafil would improve vascular function in diabetic rats. EXPERIMENTAL APPROACH Male Wistar rats were injected with streptozotocin (50 mg kg(-1), i.v.) to induce insulin-deficient diabetes. Direct effects of sildenafil as well as modification of endothelium-dependent and -independent vasorelaxation were investigated in vitro… CONTINUE READING
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