Improvement of the physicochemical properties of Co-amorphous naproxen-indomethacin by naproxen-sodium.

@article{Beyer2017ImprovementOT,
  title={Improvement of the physicochemical properties of Co-amorphous naproxen-indomethacin by naproxen-sodium.},
  author={Andreas M Beyer and Holger Grohganz and Korbinian L{\"o}bmann and Thomas Rades and Claudia Sabine Leopold},
  journal={International journal of pharmaceutics},
  year={2017},
  volume={526 1-2},
  pages={
          88-94
        }
}
Improvement of the physicochemical properties of amorphous active pharmaceutical ingredients (APIs) applying the concept of co-amorphisation is a promising alternative to the use of polymer glass solutions. In co-amorphous systems, the physical stability and the dissolution rate of the involved components may be improved in comparison to the respective single amorphous phases. However, for the co-amorphous naproxen-indomethacin model system it has been reported that recrystallization could not… CONTINUE READING
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