Improvement of the metabolic status recovers cardiac potassium channel synthesis in experimental diabetes.

@article{TorresJcome2013ImprovementOT,
  title={Improvement of the metabolic status recovers cardiac potassium channel synthesis in experimental diabetes.},
  author={Juli{\'a}n Torres-J{\'a}come and Monica Ramos Gallego and J M Rodr{\'i}guez-Robledo and Jos{\'e} Antonio S{\'a}nchez-Chapula and Oscar C{\'a}sis},
  journal={Acta physiologica},
  year={2013},
  volume={207 3},
  pages={447-59}
}
AIMS The fast transient outward current, I(to,fast) , is the most extensively studied cardiac K(+) current in diabetic animals. Two hypotheses have been proposed to explain how type-1 diabetes reduces this current in cardiac muscle. The first one is a deficiency in channel expression due to a defect in the trophic effect of insulin. The second one proposes flawed glucose metabolism as the cause of the reduced I(to,fast) . Moreover, little information exists about the effects and possible… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
8 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…