Improvement of the circulatory function partially accounts for the neuroprotective action of the phytoestrogen genistein in experimental ischemic stroke.

@article{Cortina2013ImprovementOT,
  title={Improvement of the circulatory function partially accounts for the neuroprotective action of the phytoestrogen genistein in experimental ischemic stroke.},
  author={Bel{\'e}n Cortina and Germ{\'a}n Torregrosa and Mar{\'i}a Castell{\'o}-Ruiz and Mar{\'i}a C. Burguete and Antonio Moscard{\'o} and Ana Catalan Latorre and Juan B. Salom and Juana Vall{\'e}s and Mar{\'i}a Teresa S{\'a}nchez Santos and Enrique Alborch},
  journal={European journal of pharmacology},
  year={2013},
  volume={708 1-3},
  pages={88-94}
}
We tested the hypothesis that the phytoestrogen genistein protects the brain against ischemic stroke by improving the circulatory function in terms of reduced production of thromboxane A2 and leukocyte-platelet aggregates, and of preserved vascular reactivity. Ischemia-reperfusion (90 min-3 days, intraluminal filament) was induced in male Wistar rats, and functional score and cerebral infarct volume were the end points examined. Genistein (10mg/kg/day) or vehicle (β-cyclodextrin) was… CONTINUE READING

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FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2017

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