Improvement of the biocompatibility of alginate/poly-L-lysine/alginate microcapsules by the use of epimerized alginate as a coating.

@article{King2003ImprovementOT,
  title={Improvement of the biocompatibility of alginate/poly-L-lysine/alginate microcapsules by the use of epimerized alginate as a coating.},
  author={Aileen Jean Fiona King and Berit L\okensgard Strand and Anne-Mari Rokstad and B{\aa}rd Kulseng and A. -S. Andersson and Gudmund Skj{\aa}k-Braek and Stellan Sandler},
  journal={Journal of biomedical materials research. Part A},
  year={2003},
  volume={64 3},
  pages={533-9}
}
Alginate/poly-L-lysine(PLL)/alginate capsules are used widely for the microencapsulation of cells. Alginate consists of guluronic acid and mannuronic acid, the ratio and sequence of which affect the properties of the alginate. Using C5-epimerases, mannuronic acid can be converted to guluronic acid in the alginate polymer. Such an enzyme, AlgE4, was used to convert blocks of mannuronic acid (M-blocks) to blocks of alternating sequence (MG-blocks). The aims of this study were 1) to investigate… CONTINUE READING
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