Improvement of tetracaine antinociceptive effect by inclusion in cyclodextrins.

Abstract

Local anesthetics (LA) are among the most important pharmacological compounds used to attenuate or eliminate pain. However, systemic toxicity is still a limitation for LA application, especially for ester-type drugs, such as tetracaine (TTC) that presents poor chemical stability (due to hydrolysis by plasma esterases). Several approaches have been used to… (More)
DOI: 10.3109/1061186X.2011.622400

Topics

  • Presentations referencing similar topics