Improvement of tetracaine antinociceptive effect by inclusion in cyclodextrins.


Local anesthetics (LA) are among the most important pharmacological compounds used to attenuate or eliminate pain. However, systemic toxicity is still a limitation for LA application, especially for ester-type drugs, such as tetracaine (TTC) that presents poor chemical stability (due to hydrolysis by plasma esterases). Several approaches have been used to… (More)
DOI: 10.3109/1061186X.2011.622400


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