Improvement of symptoms in infant colic following reduction of lactose load with lactase.

@article{Kanabar2001ImprovementOS,
  title={Improvement of symptoms in infant colic following reduction of lactose load with lactase.},
  author={Dipak J Kanabar and Manjit Randhawa and Paul Clayton},
  journal={Journal of human nutrition and dietetics : the official journal of the British Dietetic Association},
  year={2001},
  volume={14 5},
  pages={
          359-63
        }
}
  • D. Kanabar, M. Randhawa, P. Clayton
  • Published 1 October 2001
  • Medicine
  • Journal of human nutrition and dietetics : the official journal of the British Dietetic Association
Transient lactose intolerance has been identified as a possible causative factor in infant colic. A double-blind randomised placebo-controlled crossover study to investigate this has been undertaken in 53 babies with symptoms of colic. Pre-incubation of the feed with lactase resulted in breath hydrogen levels and total crying time which were both at least 45% lower than figures with placebo treatment, in 26% of the full trial group (95% confidence interval 12.9% to 44.4%), and in 38% of… 

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References

SHOWING 1-10 OF 34 REFERENCES

A trial of lactase in the management of infant colic

TLDR
The response to lactase in this study supports ‘colic’, i.e. spasm of the large intestine as a factor in these infants’ discomfort.

Dietary treatment of infant colic: a double-blind study.

  • J. P. Campbell
  • Medicine
    The Journal of the Royal College of General Practitioners
  • 1989
TLDR
The possible role of cows milk intolerance in the aetiology of infant colic was evaluated in 19 babies presenting to their health visitor or general practitioner in one town, and in 13 out of 19 babies (68%) the symptoms of infant Colic resolved almost completely with dietary change.

Infantile colic and type of milk feeding.

TLDR
The results suggest that dietary protein hypersensitivity is probably not the cause of colic in most healthy young infants.

Breath hydrogen excretion in infants with colic.

TLDR
No definite recommendations about the use of intravenous immunoglobulin in HIV infected children can be made, and its indiscriminate use should be discouraged.

Infantile colic. Association with lactose and milk intolerance.

TLDR
It is suggested that tolerance to lactose and cow's milk protein does not have a significant role in infantile colic.

Simethicone in the treatment of infant colic: a randomized, placebo-controlled, multicenter trial.

TLDR
Although both produced perceived improvements in symptoms, simethicone is no more effective than placebo in the treatment of infantile colic.

Breath hydrogen response to milk containing lactose in colicky and noncolicky infants.

Infantile colic. Is it a gut issue?

Colonic hydrogen production in infants with colic.

Treatment of Infantile Colic with Surface Active Substance (Simethicone)

TLDR
No effects of Simethicone on the symptoms of infantile colic could be demonstrated, however, 67 % of the infants improved during the treatment, which could be ascribed to a high‐grade placebo‐effect.