Improvement of survival of skin flaps by combined gene transfer of hepatocyte growth factor and prostacyclin synthase.

@article{Nakagawa2007ImprovementOS,
  title={Improvement of survival of skin flaps by combined gene transfer of hepatocyte growth factor and prostacyclin synthase.},
  author={Aya Nakagawa and Hirofumi Makino and Motokuni Aoki and Takashi Miyake and Suguru Shiraya and Toshikazu Nakamura and Toshio Ogihara and Yoshihiro Kimata and Ryuichi Morishita},
  journal={The journal of gene medicine},
  year={2007},
  volume={9 12},
  pages={1087-94}
}
BACKGROUND Increasing the local blood flow is a critical factor for long-term survival of skin flaps. Thus, a molecular therapy to increase the blood flow by means of an angiogenic factor is considered to be a useful strategy to improve skin flap survival. We focused on a combined strategy to stimulate not only angiogenesis, but also vasodilation of local microvessels, using co-transfection of the hepatocyte growth factor (HGF) and prostacyclin synthase (PGIS) genes to enhance the survival of… CONTINUE READING