Improvement of solubility and targetability of radioiodinated hypericin by using sodium cholate based solvent in rat models of necrosis.

@article{Ji2014ImprovementOS,
  title={Improvement of solubility and targetability of radioiodinated hypericin by using sodium cholate based solvent in rat models of necrosis.},
  author={Yun Tao Ji and Ying Zhan and Cuihua Jiang and Xiao Jiang and Meng Gao and Wei Liu and Yufeng Li and Junhu Wang and Qingqing Wang and Marlein Cona and Nan Yao and Xiaoning Wang and Zhijun Fang and Zhiqi Yin and Jian Zhang and Ziping Frank Sun and Yicheng Ni},
  journal={Journal of drug targeting},
  year={2014},
  volume={22 4},
  pages={
          304-12
        }
}
Hypericin (Hyp) is newly recognized as a necrosis avid agent, but its poor solubility imposes a great hindrance in clinical application. The aim of this paper was to explore sodium cholate (NaCh) as a potential solvent for Hyp and assess the targetability of (131)I-Hyp in rat necrosis models. Hyp solubility in NaCh solutions was evaluated by equilibrium solubility measurement. Biodistribution of (131)I-Hyp in NaCh solutions and mixed organic solvents was investigated in rat models of liver and… CONTINUE READING

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