Improvement of sleep quality in elderly people by controlled-release melatonin.

@article{Garfinkel1995ImprovementOS,
  title={Improvement of sleep quality in elderly people by controlled-release melatonin.},
  author={Doron Garfinkel and Moshe Laudon and Dina Nof and Nava Zisapel},
  journal={Lancet},
  year={1995},
  volume={346 8974},
  pages={541-4}
}
Melatonin, produced by the pineal gland at night, has a role in regulation of the sleep-wake cycle. Among elderly people, even those who are healthy, the frequency of sleep disorders is high and there is an association with impairment of melatonin production. We investigated the effect of a controlled-release formulation of melatonin on sleep quality in 12 elderly subjects (aged 76 [SD 8] years) who were receiving various medications for chronic illnesses and who complained of insomnia. In all… CONTINUE READING

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