Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha.

Abstract

OBJECTIVE Mitochondrial reactive oxygen species (ROS) plays a key role in diabetic retinopathy (DR) pathogenesis. However, whether simvastatin decreases diabetes-induced mitochondrial ROS production remains uncertain. The aim of this study was to clarify the beneficial effects and mechanism of action of simvastatin against diabetes-induced retinal vascular… (More)
DOI: 10.2337/db10-0638

Topics

Cite this paper

@article{Zheng2010ImprovementOR, title={Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha.}, author={Zhi Zheng and Haibing Chen and Hong Wang and Bilian Ke and Bingqing Zheng and Qian Li and Peiyu Li and Li Su and Qing Gu and Xun Xu}, journal={Diabetes}, year={2010}, volume={59 9}, pages={2315-25} }