Improvement of relaxation in an atherosclerotic artery by gene transfer of endothelial nitric oxide synthase.

@article{Ooboshi1998ImprovementOR,
  title={Improvement of relaxation in an atherosclerotic artery by gene transfer of endothelial nitric oxide synthase.},
  author={Hiroaki Ooboshi and Kazunori Toyoda and Frank M. Faraci and Molly G Lang and Donald D. Heistad},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1998},
  volume={18 11},
  pages={1752-8}
}
Gene transfer with replication-deficient adenovirus is a useful tool to study vascular biology. We have reported that overexpression of endothelial nitric oxide (NO) in carotid arteries from normal rabbits augments vasorelaxation mediated by NO. In this study, we tested the hypothesis that adenovirus-mediated gene transfer of endothelial nitric oxide synthase (eNOS) improves impaired relaxation of atherosclerotic vessels. We used 2 replication-deficient adenoviruses: AdeNOS, which carries cDNA… CONTINUE READING