Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction.

@article{Heusch2008ImprovementOR,
  title={Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction.},
  author={Gerd Heusch and Andreas Skyschally and Petra Gres and Patrick van Caster and Dustin Schilawa and Rainer Schulz},
  journal={European heart journal},
  year={2008},
  volume={29 18},
  pages={2265-75}
}
AIMS Effects of the bradycardic agent ivabradine on regional blood flow, contractile function, and infarct size were studied in a pig model of myocardial ischaemia/reperfusion. Heart rate reduction by beta-blockade is associated with negative inotropism and unmasked alpha-adrenergic coronary vasoconstriction. Ivabradine is the only available bradycardic agent for clinical use. METHODS AND RESULTS Anaesthetized pigs were subjected to 90 min controlled left anterior descending coronary artery… CONTINUE READING
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