Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants.

@article{Thorleifsdottir2012ImprovementOP,
  title={Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants.},
  author={Ragna Hlin Thorleifsdottir and Sigrun Laufey Sigurdardottir and Bardur Sigurgeirsson and J{\'o}n Hjaltal{\'i}n {\'O}lafsson and Martin I. Sigurdsson and Hannes Petersen and Sigurlaug {\'A}rnad{\'o}ttir and Johann E Gudjonsson and Andrew Johnston and Helgi Valdimarsson},
  journal={Journal of immunology},
  year={2012},
  volume={188 10},
  pages={
          5160-5
        }
}
Exacerbation of chronic psoriasis can be associated with streptococcal throat infections, and T cells that respond to peptide sequences common to streptococcal M proteins and skin keratins have been detected in patients' blood. To our knowledge, we have conducted the first blinded, prospective study to assess the impact of tonsillectomy on psoriasis. Twenty-nine patients with chronic psoriasis and history of exacerbation after sore throat were randomly assigned to tonsillectomy (n = 15) or… CONTINUE READING

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