Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies.

  title={Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies.},
  author={R TBorchardt and Jeffrey and Siahaan and Gangwar and Pauletti},
  journal={Advanced drug delivery reviews},
  volume={27 2-3},
Clinical development of orally active peptide drugs has been restricted by their unfavorable physicochemical properties, which limit their intestinal mucosal permeation and their lack of stability against enzymatic degradation. Successful oral delivery of peptides will depend, therefore, on strategies designed to alter the physicochemical characteristics of these potential drugs, without changing their biological activity, in order to overcome the physical and biochemical barrier properties of… CONTINUE READING

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