Improvement of neurological recovery and stimulation of neural progenitor cell proliferation by intrathecal administration of Sonic hedgehog.

@article{Bambakidis2012ImprovementON,
  title={Improvement of neurological recovery and stimulation of neural progenitor cell proliferation by intrathecal administration of Sonic hedgehog.},
  author={Nicholas C. Bambakidis and Mary Petrullis and Xu Kui and Brian D Rothstein and Ioannis Karampelas and Youzhi Kuang and Warren Selman and Joseph C. LaManna and Robert H. Miller},
  journal={Journal of neurosurgery},
  year={2012},
  volume={116 5},
  pages={1114-20}
}
OBJECT Sonic hedgehog (Shh) is a glycoprotein molecule that has been shown to be associated with the proliferative capacity of endogenous neural precursor cells during embryonic development. It has also been shown to regulate the proliferative capacity of neural stem cells in the adult subventricular zone (SVZ), which are also upregulated in animal models of ischemic stroke. In the present study, the effects of exogenous administration of intrathecal Shh protein were examined in the setting of… CONTINUE READING

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