Improvement of mitochondrial toxicity in patients receiving a nucleoside reverse-transcriptase inhibitor-sparing strategy: results from the Multicenter Study with Nevirapine and Kaletra (MULTINEKA).

@article{Negredo2009ImprovementOM,
  title={Improvement of mitochondrial toxicity in patients receiving a nucleoside reverse-transcriptase inhibitor-sparing strategy: results from the Multicenter Study with Nevirapine and Kaletra (MULTINEKA).},
  author={Eug{\`e}nia Negredo and O Scar Mir{\'o} and Benjam{\'i} Rodr{\'i}guez-Santiago and Gl{\'o}ria Garrabou and Carla Estany and Angels Masabeu and Llu{\'i}s Force and P. Barrufet and Josep Cucurull and Pere Domingo and Carlos Jos{\'e} Alonso-Villaverde and Anna Bonjoch and Constanza Mor{\'e}n and N{\'u}ria P{\'e}rez-{\'A}lvarez and Bonaventura Clotet},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2009},
  volume={49 6},
  pages={892-900}
}
BACKGROUND Nucleoside reverse-transcriptase inhibitor (NRTI)-related mitochondrial toxicity has been suggested as a key factor in the induction of antiretroviral-related lipoatrophy. This study aimed to evaluate in vivo the effects of NRTI withdrawal on mitochondrial parameters and body fat distribution. METHODS A multicenter, prospective, randomized trial assessed the efficacy and tolerability of switching to lopinavir-ritonavir plus nevirapine (nevirapine group; n = 34), compared with… CONTINUE READING

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