Improvement of islet graft function using liraglutide is correlated with its anti‐inflammatory properties

@inproceedings{Langlois2016ImprovementOI,
  title={Improvement of islet graft function using liraglutide is correlated with its anti‐inflammatory properties},
  author={Allan Langlois and St{\'e}phanie Dal and Kevin Vivot and C Mura and Elodie Seyfritz and William Bietiger and Camille Dollinger and Claude P{\'e}ronet and E Maillard and Michel Pinget and Nathalie Jeandidier and S{\'e}verine Sigrist},
  booktitle={British journal of pharmacology},
  year={2016}
}
BACKGROUND AND PURPOSE Liraglutide improves the metabolic control of diabetic animals after islet transplantation. However, the mechanisms underlying this effect remain unknown. The objective of this study was to evaluate the anti-inflammatory and anti-oxidative properties of liraglutide on rat pancreatic islets in vitro and in vivo. EXPERIMENTAL APPROACH In vitro, rat islets were incubated with 10 μmol·L-1 liraglutide for 12 and 24 h. Islet viability functionality was assessed. The anti… CONTINUE READING
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