Improvement of islet engrafts by enhanced angiogenesis and microparticle-mediated oxygenation.

  title={Improvement of islet engrafts by enhanced angiogenesis and microparticle-mediated oxygenation.},
  author={Leila Montazeri and Shahriar Hojjati-Emami and Shahin H Bonakdar and Yaser Tahamtani and Ensiyeh Hajizadeh-Saffar and Marjan Noori-Keshtkar and Mostafa Najar-Asl and Mohammad Kazemi Ashtiani and Hossein Baharvand},
A major hindrance in islet transplantation as a feasible therapeutic approach for patients with type 1 diabetes is the insufficient oxygenation of the grafts, which results in cell death in portions of the implant. Here we address this limitation through the application of oxygen-generating microparticles (MP) and a fibrin-conjugated heparin/VEGF collagen scaffold to support cell survival by using a β cell line and pancreatic rat islets. MP are composed of a polyvinylpyrrolidone/hydrogen… CONTINUE READING
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Free Radicals and Islet Function. Systems Biology of Free Radicals and Antioxidants 2014:3339-60

  • J Acharya, S. Ghaskadbi
  • 2014
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