Improvement of insulin sensitivity for glucose metabolism with the long-acting Ca-channel blocker amlodipine in essential hypertensive subjects.

@article{Harano1995ImprovementOI,
  title={Improvement of insulin sensitivity for glucose metabolism with the long-acting Ca-channel blocker amlodipine in essential hypertensive subjects.},
  author={Yutaka Harano and Asako Kageyama and Junko Hirose and Yasushi Asakura and Takashi Yokota and Makoto Ikebuchi and Masanori Suzuki and Teruo Omae},
  journal={Metabolism: clinical and experimental},
  year={1995},
  volume={44 3},
  pages={315-9}
}
To clarify whether the long-acting calcium-channel blocker amlodipine restores insulin insensitivity in essential hypertension, insulin sensitivity tests were performed at the physiological steady-state insulin level (45 to 55 microU/mL) before and after amlodipine (2.5 to 7.5 mg/d) administration for 2 to 4 months in borderline and mild essential hypertensive subjects. Instead of somatostatin, Sandostatin (Sandoz, Basel, Switzerland) was used for the determination of steady-state plasma… CONTINUE READING