Improvement of insulin sensitivity and cardiovascular outcomes in the JCR:LA-cp rat by D-fenfluramine

@article{Russell1998ImprovementOI,
  title={Improvement of insulin sensitivity and cardiovascular outcomes in the JCR:LA-cp rat by D-fenfluramine},
  author={James C. Russell and Peter J. Dolphin and Sandra E. Graham and Robert M. Amy and David N. Brindley},
  journal={Diabetologia},
  year={1998},
  volume={41},
  pages={380-389}
}
Obese male rats of the JCR:LA-cp strain are insulin resistant, normoglycaemic, hypertriglyceridaemic, and atherosclerosis-prone. Such rats were treated from 6 to 39 weeks of age with 5 mg · kg–1· day–1 of d-fenfluramine. The treatment normalised food intake, after 20 weeks of age, to that of lean control animals. At 39 weeks, treated rats weighed about 650… CONTINUE READING