Improvement of heart allograft acceptability associated with recruitment of CD4+CD25+ T cells in peripheral blood by recipient treatment with granulocyte colony-stimulating factor.

@article{Liang2008ImprovementOH,
  title={Improvement of heart allograft acceptability associated with recruitment of CD4+CD25+ T cells in peripheral blood by recipient treatment with granulocyte colony-stimulating factor.},
  author={Hongliang Liang and Dinghua Yi and Qiang Zheng and J. F. Du and Yu Xia Cao and Shi Qin Yu and Hong Ling Zhu},
  journal={Transplantation proceedings},
  year={2008},
  volume={40 5},
  pages={1604-11}
}
BACKGROUND Granulocyte colony-stimulating factor (G-CSF), an important hematopoietic growth factor of the myeloid lineage, exerts profound immunoregulatory effects in T-cell tolerance. The study objective was to investigate the potential mechanism of G-CSF's antirejection effects in a fully mismatched rat cardiac allograft model. METHODS The allograft recipients were treated with subcutaneous injection of recombinant human G-CSF (rh-G-CSF) at a dose of 250 microg/kg/d for 6 days starting from… CONTINUE READING