Improvement of hallucinogen persisting perception disorder (HPPD) with oral risperidone: case report

  title={Improvement of hallucinogen persisting perception disorder (HPPD) with oral risperidone: case report},
  author={Narayanan Subramanian and Michael Doran},
  journal={Irish Journal of Psychological Medicine},
  pages={47 - 49}
We describe a 38-year-old woman who developed symptoms of hallucinogen persisting perception disorder (HPPD) after using lysergic acid diethylamide (LSD) once and continued to have symptoms of HPPD for nearly 17 years, although she did not use LSD after her first use. The symptoms of HPPD were temporally related to her first LSD use and she responded well to risperidone within a few weeks of commencing on the same. Although different medications have been tried in the management of HPPD… 
A Review of Hallucinogen Persisting Perception Disorder (HPPD) and an Exploratory Study of Subjects Claiming Symptoms of HPPD.
Results of the survey suggest that HPPD is in most cases due to a subtle over-activation of predominantly neural visual pathways that worsens anxiety after ingestion of arousal-altering drugs, including non-hallucinogenic substances.
Hallucinogenic Persisting Perception Disorder: A Case Series and Review of the Literature
The clinical characteristics and investigation findings of a series of Hallucinogen persisting perception disorder cases with a literature review of previous case reports are reported, drawing parallels between the features of HPPD and Visual Snow Syndrome.
Hallucinogen persisting perceptual disorder: a scoping review covering frequency, risk factors, prevention and treatment.
The renewed interest in psychedelics for select mental disorders, especially agents with hallucinogenic potential provides the impetus to characterize Hallucinogen persisting perception disorder in its frequency, risk and protective factors, key characteristics, as well as other clinical and treatment related factors.
The “Endless Trip” among the NPS Users: Psychopathology and Psychopharmacology in the Hallucinogen-Persisting Perception Disorder. A Systematic Review
A critical mini review on psychopathological bases, etiological hypothesis, and psychopharmacological approaches toward HPPD, including the association with some novel substances, are provided here, by means of a literature search on PubMed/Medline, Google Scholar, and Scopus databases without time restrictions.
Novel Psychoactive Drugs
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  • Psychology
    Frontiers Research Topics
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s excluded, with reasons (n = 38): Duplicates (n = 31) Not written in English (n = 7) Full-text articles excluded, with reasons (n = 198): Reviews/commentaries/letters/meta-analysis (n = 6) Full-text
Flashbacks und anhaltende Wahrnehmungsstörungen nach Einnahme von serotonergen Halluzinogenen
Serotonerge Halluzinogene wie LSD und Psilocybin besitzen kein abhangigkeitserzeugendes Potenzial und zeigen eine niedrige Toxizitat. Sie stehen jedoch im Verdacht, das Auftreten von Storungsbildern


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Two out-patients with LSD-induced HPPD were successfully treated with clonazepam, which has serotonergic properties, and reported a marked improvement and only mild symptomatology which persisted during a six month follow-up period.
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The results of the present study indicate that it is distinctly unusual for progression of a majority of the signs and symptoms of the disease to occur after the patient has been in hospital and that in one-third of untreated patients a considerable remission of fever will occur within forty-eight hours of admission to hospital.
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Lysergic Acid Diethylamide (LSD) is a hallucinogenic drug that received considerable attention in the 1960's and early 1970's. It produced a wide variety of psychological phenomena, including a
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