Improvement of effect of water-in-oil microemulsion as an oral delivery system for fexofenadine: in vitro and in vivo studies

@inproceedings{Gundogdu2011ImprovementOE,
  title={Improvement of effect of water-in-oil microemulsion as an oral delivery system for fexofenadine: in vitro and in vivo studies},
  author={Evren Gundogdu and Isabel Gonz{\'a}lez Alvarez and Erc{\"u}ment Karasulu},
  booktitle={International journal of nanomedicine},
  year={2011}
}
Fexofenadine (FEX) has high solubility and low permeability (BCS, Class III). In this work, novel FEX loaded water in oil microemulsion (w/o) was designed to improve bioavailability and compared with Fexofen(®) syrup in in vitro and in vivo studies. In addition, pharmacokinetic parameters in permeability studies were estimated by using WinNonLin software program. w/o microemulsion system was optimized using a pseudoternary phase diagram, composed of span 80/lutrol F 68 (9.5:0.5 w/w), oleic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 31 references

Fexofenadine hydrochloride. Profiles of Drug Substances, Excipients and Related Methodology

  • L Kumar, MS Alam, CL Meena, R Jain, AK. Bansal
  • y. Powered by TCPDF (www.tcpdf.org)
  • 2009
1 Excerpt

Similar Papers

Loading similar papers…