Improvement of cytotoxic and apoptogenic properties of crocin in cancer cell lines by its nanoliposomal form.

@article{Mousavi2011ImprovementOC,
  title={Improvement of cytotoxic and apoptogenic properties of crocin in cancer cell lines by its nanoliposomal form.},
  author={Seyed Mohammad Hadi Mousavi and Seyed Adel Moallem and Soghra Mehri and Shabnam Shahsavand and Horiyeh Nassirli and Bizhan Malaekeh-Nikouei},
  journal={Pharmaceutical biology},
  year={2011},
  volume={49 10},
  pages={1039-45}
}
OBJECTIVE Saffron Crocus sativus L. (Iridaceae) is known for anticancer properties. However, limited effort has been made to correlate these effects to the active ingredients of saffron. In the present study, cytotoxic effects of crocin, the major coloring compound in saffron, and its nanoliposomal form for better cellular delivery are investigated. METHODS HeLa and MCF-7 cells were cultured and exposed to crocin (1, 2, and 4 mM) and liposomal crocin (0.5 and 1 mM). The 3-(4,5-dimethyl… CONTINUE READING

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