Improvement of cognitive deficits and decreased cholinergic neuronal cell loss and apoptotic cell death following neurotrophin infusion after experimental traumatic brain injury.

@article{Sinson1997ImprovementOC,
  title={Improvement of cognitive deficits and decreased cholinergic neuronal cell loss and apoptotic cell death following neurotrophin infusion after experimental traumatic brain injury.},
  author={Grant P. Sinson and Brian Perri and John Q. Trojanowski and Eugene S. Flamm and T K Mcintosh},
  journal={Journal of neurosurgery},
  year={1997},
  volume={86 3},
  pages={511-8}
}
This study explores the effects of infusion of nerve growth factor (NGF) on behavioral outcome and cell death in the septal region using the clinically relevant model of fluid-percussion brain injury in the rat. Animals were subjected to fluid-percussion brain injury and 24 hours later a miniosmotic pump was implanted to infuse NGF (12 animals) or vehicle (12 animals) directly into the region of maximum injury for 2 weeks. Four weeks postinjury the animals were tested for cognitive function… CONTINUE READING

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