Improvement of cardiac function after implanting the osteopontin-derived peptide SVVYGLR in a hamster model of dilated cardiomyopathy.

  title={Improvement of cardiac function after implanting the osteopontin-derived peptide SVVYGLR in a hamster model of dilated cardiomyopathy.},
  author={Y. Mizuno and A. Uchinaka and Y. Horii and S. Mori and Y. Hamada and S. Miyagawa and A. Saito and Y. Sawa and N. Matsuura and N. Kawaguchi},
  journal={Interactive cardiovascular and thoracic surgery},
  volume={21 4},
OBJECTIVES Osteopontin is a multifunctional cytokine that can modulate a variety of cellular activities, such as fibrotic response and inflammation. Osteopontin-derived peptide Ser-Val-Val-Tyr-Gly-Leu-Arg (SVVYGLR; SV) induces angiogenesis and the expression of smooth muscle actin (SMA) in fibroblasts. In this study, we determined the effects of SV peptide on dilated cardiomyopathy (DCM). METHODS Gels containing SV peptide (SV group), a random SV peptide (GYRVLSV) (random group) or a simple… Expand
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Osteopontin-derived peptide SVVYGLR induces angiogenesis in vivo.
Enhanced bone regeneration via multimodal actions of synthetic peptide SVVYGLR on osteoprogenitors and osteoclasts.
Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold biomaterials.
Angiogenic activity of osteopontin-derived peptide SVVYGLR.
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