Improvement of carcinoembryonic antigen-specific prodrug gene therapy for experimental colon cancer.

@article{Ueda2003ImprovementOC,
  title={Improvement of carcinoembryonic antigen-specific prodrug gene therapy for experimental colon cancer.},
  author={Kentaro Ueda and Makoto Iwahashi and Mikihito Nakamori and Masaki Nakamura and Ichiro Matsuura and Toshiyasu Ojima and Hiroki Yamaue},
  journal={Surgery},
  year={2003},
  volume={133 3},
  pages={309-17}
}
BACKGROUND Improvement of tumor-specific gene expression is very important for achieving successful effects in prodrug gene therapy for advanced cancer with metastatic lesions. We used the Cre/loxP system for enhancing carcinoembryonic antigen (CEA)-specific prodrug gene therapy of cytosine (CD)/5-fluorocytosine (5-FC) for the treatment of a colon cancer model accompanied with liver metastases. METHODS Orthotopic colon cancer models were developed. Seven days later, adenovirus vector (3 x 10… CONTINUE READING

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