Improvement of Cephalosporin C Production by Recombinant DNA Integration in Acremonium chrysogenum

@article{Liu2010ImprovementOC,
  title={Improvement of Cephalosporin C Production by Recombinant DNA Integration in Acremonium chrysogenum},
  author={Yan Liu and Guihua Gong and Liping Xie and Ning Yuan and Chunbao Zhu and Baoquan Zhu and Youjia Hu},
  journal={Molecular Biotechnology},
  year={2010},
  volume={44},
  pages={101-109}
}
Cephalosporins are widely used as anti-infectious β-lactam antibiotics in clinic. For the purpose of increasing the yield of cephalosporin C (CPC) fermentation, especially in an industrial strain, A. chrysogenum genes cefEF and cefG, which encode the ultimate and penultimate steps in CPC biosynthesis, cefT, which encodes a CPC efflux pump, and vgb, which encodes a bacterial hemoglobin gene were transformed in various combinations into an industrial strain of A. chrysogenum. Both PCR and… CONTINUE READING
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