Improvement in solubility and dissolution rate of flavonoids by complexation with beta-cyclodextrin.

@article{Tommasini2004ImprovementIS,
  title={Improvement in solubility and dissolution rate of flavonoids by complexation with beta-cyclodextrin.},
  author={Silvana Tommasini and Daniela Raneri and Rita Ficarra and Maria Luisa Calabr{\'o} and Rosanna Stancanelli and Paola Ficarra},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2004},
  volume={35 2},
  pages={379-87}
}
The inclusion into the beta-cyclodextrin is used to improve pharmacokinetic characteristics of hesperetin and naringenin. Solubility of hesperetin and naringenin with increasing concentrations of beta-cyclodextrin grows as long as the temperature increased. Stability constants were determined by the solubility method by Higuchi and Connors at different temperatures, and the thermodynamic parameters were calculated for inclusion complex formation in aqueous solution. The solid complexes were… CONTINUE READING

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