Improvement in skin barrier function in patients with atopic dermatitis after treatment with a moisturizing cream (Canoderm®)

@article{Lodn1999ImprovementIS,
  title={Improvement in skin barrier function in patients with atopic dermatitis after treatment with a moisturizing cream (Canoderm{\textregistered})},
  author={Lod{\'e}n and Andersson and Lindberg},
  journal={British Journal of Dermatology},
  year={1999},
  volume={140}
}
Patients with atopic skin show a defective barrier function both in rough and in clinically normal skin, with an increasing risk of developing contact dermatitis. Moisturizing creams are often used in the treatment of dry skin. The purpose of this study was to investigate the influence of treatment with a urea‐containing moisturizer on the barrier properties of atopic skin. Fifteen patients with atopic dermatitis treated one of their forearms twice daily for 20 days with a moisturizing cream… 
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Improvement of skin barrier function in atopic dermatitis patients with a new moisturizer containing a ceramide precursor
TLDR
Skin barrier function and hydration were significantly improved after CRM treatment, and a significantly higher level of ceramide and a trend toward increased water content was observed with Raman in the SC for CRM than for the control.
Gentle Cleansing and Moisturizing for Patients with Atopic Dermatitis and Sensitive Skin
  • W. Cheong
  • Medicine
    American journal of clinical dermatology
  • 2009
TLDR
Moisturizers improve skin hydration, reduce susceptibility to irritation, restore the integrity of the stratum corneum, and enhance the efficacy of topical corticosteroids and immunosuppressive agents.
The effect of two urea-containing creams on dry, eczematous skin in atopic patients. I. Expert, patient and instrumental evaluation
TLDR
In a randomized double-blind study, the effects of a new moisturizing cream were compared with those of an already registered medicinal cream in the treatment of dry, eczematous skin in atopic patients, using multiple methods.
Reevaluation of the Importance of Barrier Dysfunction in the Nonlesional Dry Skin of Atopic Dermatitis Patients through the Use of Two Barrier Creams
TLDR
It is likely that the recovery of barrier function reflects the improvement in clinically evaluated dry skin conditions of the nonlesional skin to a greater extent than that in water deficiency, which suggests that the barrier-replenishing effect is a more important factor for treatment of AD nonlesion skin than is the improvement of water deficiency.
Improvement of Mild Inflammatory Changes of the Facial Skin Induced by Winter Environment with Daily Applications of a Moisturizing Cream
TLDR
A half-side test on the face suggested that the daily application of a moisturizing cream is effective in improving mild subclinical inflammation that is induced on the facial skin by the winter environment.
Stratum corneum hydration and skin surface pH in patients with atopic dermatitis.
TLDR
The results of this study suggested the skin barrier function to be degraded in AD patients, which is specifically expressed in lesional skin.
Effect of moisturizers on epidermal barrier function.
Nickel Susceptibility and Skin Barrier Function to Water after Treatment with a Urea-Containing Moisturizer
TLDR
The absence in correlation between TEWL and skin susceptibility to nickel suggests different penetration pathways through the skin of water and nickel, which suggests different therapeutic efficacy in the prevention of contact eczema due to exposure to harmful exogenous substances.
Beneficial effects of a skin tolerance‐tested moisturizing cream on the barrier function in experimentally‐elicited irritant and allergic contact dermatitis
TLDR
It was observed that repeated cream application significantly improved the TEWL of SLS‐damaged skin, leading to a complete recovery on day 15, showing that recovery of the disrupted skin significantly improved after cream application in comparison to untreated barrier repair.
The Role of Skin Moisturizers in the Prevention of Irritant Contact Dermatitis – A Review
  • C. Goh
  • Medicine
    Exogenous Dermatology
  • 2002
TLDR
There has been sufficient evidence to suggest that moisturizers can prevent irritant contact dermatitis and should be recommended to workers who are constantly exposed to contact irritants.
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References

SHOWING 1-10 OF 25 REFERENCES
Barrier recovery and influence of irritant stimuli in skin treated with a moisturizing cream
TLDR
The accelerated rate of recovery of surfactant‐damaged skin and the lower degree of SLS‐induced irritation in normal skin treated with the test cream may be of clinical relevance in attempts to reduce contact dermatitis due to irritant stimuli.
Effect of long-term use of moisturizer on skin hydration, barrier function and susceptibility to irritants.
TLDR
The results suggest that long-term treatment with moisturizers on normal skin may increase skin susceptibility to irritants.
Biophysical properties of dry atopic and normal skin with special reference to effects of skin care products.
  • M. Lodén
  • Medicine
    Acta dermato-venereologica. Supplementum
  • 1995
TLDR
The study suggests that measurement of skin friction can be used to predict the degree of liking of moisturizers, and that skin care products may penetrate and influence the structure and function of the skin.
The importance of skin barrier function
The prevalence of atopic eczema and other dry skin conditions is increasing, suggesting that environmental factors are of major importance in its aetiology. The stratum corneum provides the epidermal…
The influence of a single application of different moisturizers on the skin capacitance.
TLDR
Findings indicate that the non-absorbed components influences the capacitance values, and the interpretation of electrical measurements with respect to skin moisture should be made with caution.
Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis.
TLDR
The TEWL was found to be increased both in dry non-eczematous skin and in clinically normal skin in patients with AD, which may indicate a primary defect in the epidermal barrier: the stratum corneum.
Abnormal skin irritancy in atopic dermatitis and in atopy without dermatitis.
TLDR
Significantly greater frequency of response to sodium lauryl sulfate in both AD groups and also in patients with allergic rhinitis with no dermatitis was seen, and it is hypothesized that abnormal intrinsic hyperreactivity in inflammatory cells, rather than in skin cells, in atopic individuals predisposes to a lowered threshold of irritant responsiveness.
The increase in skin hydration after application of emollients with different amounts of lipids.
  • M. Lodén
  • Medicine
    Acta dermato-venereologica
  • 1992
TLDR
Emollients can increase the water content in the stratum corneum by delivery of their water to the skin, and by occlusion, which resulted in a release of water following removal of the products.
Effect of topically applied lipids on surfactant‐irritated skin
TLDR
The influence of a single application of nine different lipids on normal skin and skin irritated by sodium lauryl sulphate was studied in 21 healthy subjects.
Atopy and hand dermatitis in hospital wet work
TLDR
The presence of atopic symptoms significantly favoured the development of hand dermatitis in these occupations and the prevalence of atopy was 32% and the frequency of past or presentHand dermatitis 44%.
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