Improvement in renal function and rejection control in pediatric liver transplant recipients with the introduction of sirolimus.

@article{CasasMelley2004ImprovementIR,
  title={Improvement in renal function and rejection control in pediatric liver transplant recipients with the introduction of sirolimus.},
  author={Adela T Casas-Melley and Kathleen P Falkenstein and Louise M Flynn and Valerie L Ziegler and Stephen P. Dunn},
  journal={Pediatric transplantation},
  year={2004},
  volume={8 4},
  pages={362-6}
}
Calcineurin inhibitors have dramatically improved the outcomes of pediatric liver transplantation. However, calcineurin inhibitor use is associated with a 50% reduction in glomerular filtration rate in the first year post-transplant. Nephrotoxicity can be difficult to manage, especially in the pediatric population. We hypothesized that the addition of an mTOR inhibitor with decreased calcineurin inhibitor levels might improve or prevent renal insufficiency and improve control of rejection. A… CONTINUE READING
12 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…