Improvement in protocol to generate homogeneous glutamatergic neurons from mouse embryonic stem cells reduced apoptosis.

@article{Fujiki2013ImprovementIP,
  title={Improvement in protocol to generate homogeneous glutamatergic neurons from mouse embryonic stem cells reduced apoptosis.},
  author={Ryosuke Fujiki and Akinobu Sato and Katsuhiko Hata and Fumi Tashiro and Noriko Yasuhara and Jun-Ichi Miyazaki and Yoshihiro Yoneda and Masashi Fujitani and Toshihide Yamashita},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={430 2},
  pages={604-9}
}
Obtaining a homogenous population of central nervous system neurons has been a significant challenge in neuroscience research; however, a recent study established a retinoic acid-treated embryoid bodies-based differentiation protocol that permits the effective generation of highly homogeneous glutamatergic cortical pyramidal neurons from embryonic stem cells. We were able to reproduce this protocol regarding the purity of glutamatergic neurons, but these neurons were not sufficiently healthy… CONTINUE READING
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