Improvement in fear memory by histamine-elicited ERK2 activation in hippocampal CA3 cells.

@article{Giovannini2003ImprovementIF,
  title={Improvement in fear memory by histamine-elicited ERK2 activation in hippocampal CA3 cells.},
  author={Maria Grazia Giovannini and Marcel Efoudebe and Maria Beatrice Passani and Elisabetta Baldi and Corrado Bucherelli and Filippo Giachi and Renato Corradetti and Patrizio Blandina},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 27},
  pages={9016-23}
}
Consolidation of associative memories appears to require extracellular signal-related kinase2 (ERK2) activation, which is modulated by several factors, including neurotransmitter receptor stimulation. Here we show that in vitro stimulation of either H2 or H3 histaminergic receptors activates ERK2 in hippocampal CA3 pyramidal cells. In behaving animals, bilateral posttraining injections into the dorsal hippocampus of histamine H2 or H3 receptor agonists improve memory consolidation after… CONTINUE READING