Improvement in endothelial function by angiotensin converting enzyme inhibition in insulin-dependent diabetes mellitus.

@article{ODriscoll1997ImprovementIE,
  title={Improvement in endothelial function by angiotensin converting enzyme inhibition in insulin-dependent diabetes mellitus.},
  author={Gerard J O'Driscoll and Daniel Green and James M. Rankin and Kim G Stanton and Roger R. Taylor},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 3},
  pages={678-84}
}
We postulated that nitric oxide (NO)-mediated endothelial function would be improved by acute and short-term treatment with an angiotensin converting enzyme (ACE) inhibitor in patients with type I diabetes mellitus, in whom endothelial function is depressed. Nine type I diabetic patients and eight healthy subjects underwent forearm blood flow measurement using strain gauge plethysmography during intraarterial infusion of incremental doses of endothelium-dependent (acetylcholine [ACh]) and… CONTINUE READING
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