Improvement in blood pressure with inhibition of the epithelial sodium channel in blacks with hypertension.

@article{Saha2005ImprovementIB,
  title={Improvement in blood pressure with inhibition of the epithelial sodium channel in blacks with hypertension.},
  author={Chandan K. Saha and George J. Eckert and Walter T. Ambrosius and T W Chun and Mary Anne Wagner and Qianqian Zhao and Joseph H. Pratt},
  journal={Hypertension},
  year={2005},
  volume={46 3},
  pages={481-7}
}
Hypertension in blacks is more prevalent and less often controlled than the hypertension of other ethnic groups. We sought to explore the benefit of adding inhibitors of the epithelial sodium channel (ENaC), an aldosterone-regulated site of sodium reabsorption in the distal nephron, to the antihypertensive regimen of black hypertensive patients. In a prospective, randomized, placebo-controlled, double-blind clinical trial, we used a 2-by-2 factorial design with 4 treatment groups: amiloride (a… CONTINUE READING
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