Improvement in baroreflex function by an oral angiotensin receptor antagonist in rats with myocardial infarction.

  title={Improvement in baroreflex function by an oral angiotensin receptor antagonist in rats with myocardial infarction.},
  author={Makoto Nishizawa and Harumitsu Kumagai and Masashi Ichikawa and Naoki Oshima and Hiromichi Suzuki and Takao Saruta},
  volume={29 1 Pt 2},
Impaired baroreflex function is a factor responsible for poor prognosis in myocardial infarction patients. Using logistic function curves, we calculated the maximal gain of the baroreflex control of renal sympathetic nerve activity (RSNA) and heart rate in conscious Wistar-Kyoto and spontaneously hypertensive rats whose left anterior descending artery had been ligated 4 weeks earlier. We further investigated whether 3-week oral treatment with the angiotensin II type 1 receptor antagonist TCV… CONTINUE READING


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