Improvement in Aerobic Capacity After an Exercise Program in Sporadic Inclusion Body Myositis

@article{Johnson2009ImprovementIA,
  title={Improvement in Aerobic Capacity After an Exercise Program in Sporadic Inclusion Body Myositis},
  author={Liam Johnson and Kelly E Collier and Dylan J. Edwards and Danielle L. Philippe and Peter R. Eastwood and Susan E. Walters and Gary W. Thickbroom and Frank L Mastaglia},
  journal={Journal of Clinical Neuromuscular Disease},
  year={2009},
  volume={10},
  pages={178-184}
}
Objectives: The study aimed to investigate the effects of a combined functional and aerobic exercise program on aerobic capacity, muscle strength, and functional mobility in a group of patients with sporadic inclusion body myositis (IBM). Methods: Aerobic capacity, muscle strength, and functional capacity assessments were conducted on 7 participants with sporadic IBM before and after a 12-week exercise program, which included resistance exercises and aerobic stationary cycling 3 times per week… 
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The effects (benefits and harms) of strength training and aerobic exercise training in people with a muscle disease diagnosis were assessed to incorporate new evidence in this active area of research.
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References

SHOWING 1-10 OF 38 REFERENCES
The Effectiveness of an Individualized, Home-Based Functional Exercise Program for Patients With Sporadic Inclusion Body Myositis
TLDR
The findings of this study indicate that an individually prescribed home exercise program can be safely implemented and can result not only in significant gains in muscle strength but also in useful improvements in functional capabilities and is therefore beneficial in the management of patients with IBM.
Sporadic inclusion body myositis: pilot study on the effects of a home exercise program on muscle function, histopathology and inflammatory reaction.
TLDR
The home exercise program was considered as not harmful to the muscles regarding muscle inflammation and function and may prevent loss of muscle strength due to disease and/or inactivity.
Safety and efficacy of strength training in patients with sporadic inclusion body myositis
TLDR
It is concluded that a supervised progressive resistance training program in IBM patients can lead to gains in dynamic strength of the least weak muscles without causing muscle fatigue and muscle injury or serological, histological, and immunological abnormalities.
Short‐term aerobic training response in chronic myopathies
TLDR
It is demonstrated that short‐term aerobic training at low intensity can benefit patients with nonmetabolic myopathies but to a lesser extent than patients with mitochondrial myopathy.
Effects of aerobic training in patients with mitochondrial myopathies
TLDR
It is suggested that aerobic training can benefit patients with mitochondrial myopathies and improvement in exercise tolerance may be due in part to reversal of the effects of secondary deconditioning.
The role of exercise in the rehabilitation of idiopathic inflammatory myopathies
TLDR
Data indicate that active exercise, adapted to disease activity and disability should be included in the rehabilitation of patients in all stages of IIM, and the newly developed and validated outcome measures for patients with polymyositis and dermatomyositis help assess the effects of interventions on diseaseactivity and disability.
Exercise therapy in patients with myopathy
TLDR
Further research is needed to determine the optimum training protocols for patients with various types of myopathy, and in particular to improve the ability of patients to be active and independent in daily life.
Aerobic exercise and muscle metabolism in patients with mitochondrial myopathy
TLDR
It is concluded that there are significant metabolic differences between patients with MM and a control population, independent of age, gender, and physical activity.
Aerobic capacity in adult dermatomyositis/polymyositis patients and healthy controls.
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