Improved workup for glycosaminoglycan disaccharide analysis using CE with LIF detection.

@article{Hitchcock2008ImprovedWF,
  title={Improved workup for glycosaminoglycan disaccharide analysis using CE with LIF detection.},
  author={Alicia M Hitchcock and Michael J. Bowman and Gregory O. Staples and Joseph Zaia},
  journal={Electrophoresis},
  year={2008},
  volume={29 22},
  pages={4538-48}
}
This work describes improved workup and instrumental conditions to enable robust, sensitive glycosaminoglycan (GAG) disaccharide analysis from complex biological samples. In the process of applying CE with LIF to GAG disaccharide analysis in biological samples, we have made improvements to existing methods. These include (i) optimization of reductive amination conditions, (ii) improvement in sensitivity through the use of a cellulose cleanup procedure for the derivatization, and (iii… CONTINUE READING

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