Improved whole-chromosome phasing for disease and population genetic studies

@article{Delaneau2012ImprovedWP,
  title={Improved whole-chromosome phasing for disease and population genetic studies},
  author={O. Delaneau and Jean-François Zagury and Jonathan Marchini},
  journal={Nature Methods},
  year={2012},
  volume={10},
  pages={5-6}
}
  • O. Delaneau, Jean-François Zagury, Jonathan Marchini
  • Published 2012
  • Medicine, Biology
  • Nature Methods
  • SHAPEIT2 uses multithreading so that multiple cores can be used to phase whole chromosomes, allowing users to make the best use of their computational resources. We tested SHAPEIT2 on several large-sample, whole-chromosome data sets from a range of SNP genotyping chips (Supplementary Note 1). SHAPEIT2 outperforms other methods (Fig. 1a–c) in terms of switch error rate (SER) and the mean distance between switch errors (Supplementary Figs. 1 and 2). As compared to SHAPEIT1, SHAPEIT2 reduced SER… CONTINUE READING

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