Improved vascular survival and growth in the mouse model of hindlimb ischemia by a remote signaling mechanism.

@article{Takeda2014ImprovedVS,
  title={Improved vascular survival and growth in the mouse model of hindlimb ischemia by a remote signaling mechanism.},
  author={Kotaro Takeda and Li-Juan Duan and Hiromi Takeda and G S Fong},
  journal={The American journal of pathology},
  year={2014},
  volume={184 3},
  pages={686-96}
}
Deficiencies in prolyl hydroxylase domain proteins (PHDs) may lead to the accumulation of hypoxia-inducible factor-α proteins, the latter of which activate local angiogenic responses by paracrine mechanisms. Here, we investigate whether a keratinocyte-specific PHD deficiency may promote vascular survival and growth in a distantly located ischemic tissue by a remote signaling mechanism. We generated mice that carry a keratinocyte-specific Phd2 knockout (kPhd2KO) and performed femoral artery… CONTINUE READING