Improved validated assay for the determination of mefloquine and its carboxy metabolite in plasma, serum and whole blood using solid-phase extraction and high-performance liquid chromatography.

@article{Green1999ImprovedVA,
  title={Improved validated assay for the determination of mefloquine and its carboxy metabolite in plasma, serum and whole blood using solid-phase extraction and high-performance liquid chromatography.},
  author={Michael Green and Yngve Bergqvist and Dwight L Mount and Steve Corbett and Martin J D'souza},
  journal={Journal of chromatography. B, Biomedical sciences and applications},
  year={1999},
  volume={727 1-2},
  pages={159-65}
}
An improved high-performance liquid chromatography method using a low silanol activity octadecylsilica column and a solid-phase extraction technique is validated for the simultaneous analysis of mefloquine and its carboxy metabolite in whole blood, plasma and serum. An octadecylsilica column with high silanol activity is compared to a column of low activity in terms of pH dependent variability of chromatographic retention times for mefloquine and its carboxy metabolite. The low silanol activity… CONTINUE READING
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