Improved treatment results in childhood B-cell neoplasms with tailored intensification of therapy: A report of the Berlin-Frankfurt-Münster Group Trial NHL-BFM 90.

  title={Improved treatment results in childhood B-cell neoplasms with tailored intensification of therapy: A report of the Berlin-Frankfurt-M{\"u}nster Group Trial NHL-BFM 90.},
  author={A. Reiter and Martin Schrappe and Markus Tiemann and W. D. Ludwig and E Yakisan and Martin Zimmermann and Georg Mann and Andreas Chott and Wolfram Ebell and Thomas Klingebiel and Norbert Graf and Bernhard Kremens and ST M{\"u}ller-Weihrich and H. J. Pl{\"u}ss and Felix Zintl and Gunter Henze and Hansjoerg Riehm},
  volume={94 10},
In study NHL-BFM 90, we investigated whether the serum lactate dehydrogenase (LDH) concentration and early response are useful markers for stratification of therapy for childhood B-cell neoplasms in addition to stage, if the outcome of patients with abdominal stage III and LDH >/=500 U/L can be improved by high-dose (HD) methotrexate (MTX) at 5 g/m(2) instead of intermediate-dose (ID) MTX at 500 mg/m(2) in the preceding study 86; whether 2 therapy courses are enough for patients with complete… CONTINUE READING
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