Improved therapeutic efficacy of mammalian expressed‐recombinant interferon gamma against ovarian cancer cells

@article{Razaghi2017ImprovedTE,
  title={Improved therapeutic efficacy of mammalian expressed‐recombinant interferon gamma against ovarian cancer cells},
  author={Ali Razaghi and C. Villacr{\'e}s and Vincent Jung and N. Mashkour and M. Butler and L. Owens and K. Heimann},
  journal={Experimental Cell Research},
  year={2017},
  volume={359},
  pages={20–29}
}
&NA; Human interferon gamma (hIFN&ggr;) affects tumour cells and modulates immune responses, showing promise as an anti‐cancer biotherapeutic. This study investigated the effect of glycosylation and expression system of recombinant hIFN&ggr; in ovarian carcinoma cell lines, PEO1 and SKOV3. The efficacy of E. coli‐ and mammalian‐expressed hIFN&ggr; (hIFN&ggr;‐CHO and HEK293, glycosylated/de‐glycosylated) on cytostasis, cell death (MTT, and Guava‐ViaCount® flow‐cytometry) and apoptotic signalling… Expand
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