Improved tests for heterogeneity across a region of DNA sequence in the ratio of polymorphism to divergence.

@article{McDonald1998ImprovedTF,
  title={Improved tests for heterogeneity across a region of DNA sequence in the ratio of polymorphism to divergence.},
  author={John H. McDonald},
  journal={Molecular biology and evolution},
  year={1998},
  volume={15 4},
  pages={377-84}
}
The neutral theory of molecular evolution predicts that the ratio of polymorphisms to fixed differences should be fairly uniform across a region of DNA sequence. Significant heterogeneity in this ratio can indicate the effects of balancing selection, selective sweeps, mildly deleterious mutations, or background selection. Comparing an observed heterogeneity statistic with simulations of the heterogeneity resulting from random phylogenetic and sampling variation provides a test of the… CONTINUE READING

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