Improved targeting of antimony to the bone marrow of dogs using liposomes of reduced size.

Abstract

A novel liposomal formulation of meglumine antimoniate (MA), consisting of vesicles of reduced size, has been evaluated in dogs with visceral leishmaniasis to determine its pharmacokinetics as well as the impact of vesicle size on the targeting of antimony to the bone marrow. Encapsulation of MA in liposomes was achieved through freeze-drying of empty… (More)

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Cite this paper

@article{Schettini2006ImprovedTO, title={Improved targeting of antimony to the bone marrow of dogs using liposomes of reduced size.}, author={Dante Alighieri Schettini and Raul Rio Ribeiro and Cynthia P Demicheli and Olguita Geralda Ferreira Rocha and Maria Norma de Melo and Marilene Suzan Marques Michalick and Fr{\'e}d{\'e}ric Jean Georges Fr{\'e}zard}, journal={International journal of pharmaceutics}, year={2006}, volume={315 1-2}, pages={140-7} }