Improved survival with bisoprolol in patients with heart failure and renal impairment: an analysis of the cardiac insufficiency bisoprolol study II (CIBIS‐II) trial

@article{Castagno2010ImprovedSW,
  title={Improved survival with bisoprolol in patients with heart failure and renal impairment: an analysis of the cardiac insufficiency bisoprolol study II (CIBIS‐II) trial},
  author={Davide Castagno and Pardeep S. Jhund and John J. V. McMurray and James Lewsey and Erland Erdmann and Faiez Zannad and Willem J. Remme and Jos{\'e} Luis L{\'o}pez-Send{\'o}n and Philippe P Lechat and Ferenc Follath and Christer H{\"o}glund and V. Yu. Mareev and Zygmunt P Sadowski and Ricardo J. Seabra-Gomes and Henry J. Dargie},
  journal={European Journal of Heart Failure},
  year={2010},
  volume={12}
}
Information on the effectiveness of beta‐blockade in patients with heart failure (HF) and concomitant renal impairment is scarce and beta‐blockers are underutilized in these patients. 
Cardiorenal syndrome: Pathophysiology, preclinical models, management and potential role of uraemic toxins
1. Cardiorenal syndrome (CRS) describes the primary dysfunction in either the kidney or heart that initiates the combined impairment of both organs. The heart and kidney exert reciprocal control of
Impact of Renal Impairment on Beta-Blocker Efficacy in Patients With Heart Failure.
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A brief summary of the pharmacotherapy of chronic heart failure as it was published in the new 2021 guidelines of the European Society of Cardiology is offered.
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It is shown that for both all-cause mortality and the combined end point of cardiovascular death or heart failure hospitalization, most drug classes are safe and effective up to CKD stage 3B, and a decline in eGFR in the context of a stable or improving clinical condition should not be cause for concern and should not lead to discontinuation of life-saving HFrEF therapies.
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TLDR
Interdisciplinary input from HF and renal specialists is required to provide integrated care for the growing number of patients with HF and CKD.
We should not hesitate to use beta-blockers for systolic heart failure with concomitant renal dysfunction.
  • N. Matsuda
  • Medicine
    Circulation journal : official journal of the Japanese Circulation Society
  • 2010
TLDR
Fear of adverse potential and limited information about long-term effects and tolerability might explain the clinical hesitation to administer β-blockers for heart failure and concomitant chronic kidney disease.
University of Groningen Impact of Renal Impairment on Beta-Blocker Efficacy in Patients With Heart Failure Beta-Blockers Heart Failure
TLDR
Patients with heart failure, left ventricular ejection fraction <50% and sinus rhythm should receive beta-blocker therapy even with moderate or moderately severe renal dysfunction, according to renal function using estimated glomerular filtration rate (eGFR).
Renal effects of guideline‐directed medical therapies in heart failure: a consensus document from the Heart Failure Association of the European Society of Cardiology
TLDR
Advice is provided of the effect HF drugs on renal function as the emerge of several new classes and the recommendation by the 2021 ESC guidelines of early initiation and titration of quadruple disease‐modifying therapies in HFrEF increases the likelihood of treatment‐induced changes in renal function.
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