Improved survival for children with B-cell acute lymphoblastic leukemia and stage IV small noncleaved-cell lymphoma: a pediatric oncology group study.

@article{Bowman1996ImprovedSF,
  title={Improved survival for children with B-cell acute lymphoblastic leukemia and stage IV small noncleaved-cell lymphoma: a pediatric oncology group study.},
  author={William Paul Bowman and Jonathan J Shuster and B. Cook and Timothy Griffin and F L Behm and Jeanette Pullen and M. Link and David Pesetsky Head and A. Victoria Carroll and C. Berard and S. Murphy},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1996},
  volume={14 4},
  pages={1252-61}
}
PURPOSE In an effort to improve outcome for children with advanced B-cell malignancies, a treatment plan based on a published regimen that consists of four courses of fractionated cyclophosphamide (cyclo) given with doxorubicin (doxo) and vincristine (VCR) was intensified by alternating with sequential high-dose methotrexate (MTX) and cytarabine (Ara-C), given in conjunction with intrathecal (IT) MTX and Ara-C. PATIENTS AND METHODS From October 1986 to October 1992, 133 eligible patients were… CONTINUE READING

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