Improved stability of polycationic vector by dextran-grafted branched polyethylenimine.

@article{Tseng2003ImprovedSO,
  title={Improved stability of polycationic vector by dextran-grafted branched polyethylenimine.},
  author={Wen-Chi Tseng and Chai-Min Jong},
  journal={Biomacromolecules},
  year={2003},
  volume={4 5},
  pages={1277-84}
}
In vivo instability of a polycationic vector limits its efficacy after systemic administration. Conjugation of hydrophilic polymers with neutral charge onto polycationic vectors has been used to improve the stability by reducing the interactions between the vectors and the blood components, such as serum albumin. In this study, dextrans of molecular weight 10000 (dex-10000) and 1500 (dex-1500) were used to produce various degrees of grafting on linear and branched polyethylenimines (PEI), and… CONTINUE READING
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