Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP

@article{Oharte2002ImprovedSI,
  title={Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP},
  author={Finbarr P M O'harte and Victor A Gault and Joanna E. Parker and Patrick Harriott and Mark H Mooney and C D Bailey and Peter Raymond Flatt},
  journal={Diabetologia},
  year={2002},
  volume={45},
  pages={1281-1291}
}
Aims/hypothesis. This study examined the plasma stability, biological activity and antidiabetic potential of two novel N-terminally modified analogues of gastric inhibitory polypeptide (GIP). Methods. Degradation studies were carried out on GIP, N-acetyl-GIP (Ac-GIP) and N-pyroglutamyl-GIP (pGlu-GIP) in vitro following incubation with either dipeptidylpeptidase IV or human plasma. Cyclic adenosine 3′5′ monophosphate (cAMP) production was assessed in Chinese hamster lung fibroblast cells… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Enhancing incretin action for the treatment of type 2 diabetes.

Diabetes care • 2003
View 8 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice.

Proceedings of the National Academy of Sciences of the United States of America • 1999
View 3 Excerpts
Highly Influenced

The entero-insular axis in type 2 diabetes--incretins as therapeutic agents.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association • 2001
View 2 Excerpts

The pathophysiology of type 2 diabetes mellitus: an overview.

Acta physiologica Scandinavica • 2001
View 1 Excerpt

Similar Papers

Loading similar papers…